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4 Thus, we hypothesized that stability is also lower in adults with schizophrenia spectrum disorders and in individuals with high cumulative polygenic risk for schizophrenia.Ĭompared with controls, individuals with schizophrenia spectrum disorders showed significantly lower stability of the connectome fingerprint for the full brain (Cohen d, −0.56 P = 2 × 10 −7) and frontoparietal ( d, −0.30 P = 5 × 10 −3), motor ( d, −0.39 P = 2 × 10 −4), visual 1 ( d, −0.37 P = 6 × 10 −4), visual association ( d, −0.44 P = 4 × 10 −5), cerebellum ( d, −0.39 P = 3 × 10 −4), and subcortical ( d, −0.56 P = 3 × 10 −7) networks after accounting for age, age squared, sex, motion, temporal signal-to-noise ratio, and scanning site ( Figure 2A). 6 The stability of the connectome captures system-level, within-participant properties of the connectome and has recently shown promise as a marker of mental health in adolescents. 3 This suggests that important individual-level information may be overlooked in common imaging approaches, which has limited the specificity and clinical utility of functional magnetic resonance imaging (fMRI). The brain functional connectome is highly individualized 3 - 5 and has been metaphorically called a fingerprint. Although disappointing from a clinical point of view, this lack of direct translation of group-level findings to the individual is in line with the substantial individual patient heterogeneity in clinical and cognitive profiles.
![thebrain 9 stability thebrain 9 stability](https://i.redd.it/v1a2at4096g41.jpg)
1 However, the diversity of findings on localization, magnitude, and clinical sensitivity the lack of robust associations with polygenic risk scores and poor diagnostic classification using machine learning 2 suggest that the discriminatory power of neuroimaging data alone is limited and that the individual brain patterns are highly heterogeneous.
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